Our research has focused on metabolism, including its biochemistry, extension, and regulation. We use metabolic engineering, synthetic biology, and systems biology to construct microorganisms to produce next generation biofuels and to study the obesity problem in human. We also develop mathematical tools for investigating metabolism and guiding engineering design.

Currently, our main projects include engineering proteins and biochemical pathways for CO2 fixation and produciton of fuels and chemicals. Our ultimate goal is to use biochemical methods to replace petroleum processing and to treat metabolic diseases.